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Ranze Eto (her given name is also Romanized as "Ransie" or "Ranzi" in some non-Japanese version) may look like your average Japanese teenage girl, but in reality she lives in an extraordinary situation. Her mother is a werewolf, and her father is a vampire. Ranze has special powers of her own: for example, whenever she bites anything, she can change herself into a carbon copy of that object, whether it's another person or an inanimate object such as a piece of bread. Only by sneezing can she return to her normal self.

On Ranze's first day at her new school, she meets and falls in love with the brash yet handsome young athlete Shun Makabe (Paul in the Italian version). The chief problem with this is that Ranze's parents will not allow her to date a human - although there may be much more to Shun than meets the eye. On top of this, Ranze also has a bitter rival in the pretty but spiteful Yoko Kamiya (Liza in the Italian anime), the daughter of a yakuza boss, who is also in love with Shun and doesn't take kindly to Ranze intruding on her turf.