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Based on the hit feature film of the same name, Honey, I Shrunk the Kids expands upon the original film's concept of a shrinking experiment gone wrong to include myriad experiments gone awry.

The syndicated series, produced between 1997 and 2000, is a one-hour comedy/adventure starring Peter Scolari as the lovable but befuddled scientist Wayne Szalinski. The well-meaning Wayne constructs a variety of inventions, including the Shrink-Ray, Neuron Nudger and Brainiactivator among others, that create predicaments for his wife Diane (Barbara Alyn Woods), their kids Amy (Hillary Tuck) and Nick (Thomas Dekker), and their friends. The series picks up with the Szalinski household relocating to Matheson, Colorado. Each episode incorporates new technologies and digital effects to feature the family in various new adventures. The series was filmed in Calgary, Alberta, with its main studios located in Currie Barracks, a decommissioned Canadian Forces dormitory.

After running for several seasons in syndication, Honey, I Shrunk the Kids: The TV Show later moved to The Disney Channel. It was last seen on the Disney Channel during the late night hours in 2004.