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Elisa Cameron is dead.

She has a sister, Margo, with whom she slowly reconciles and moves in with, as well as two recently sober parents, who are eventually murdered by a shadowy psionic that seems to know something about her past as a reporter, apparently slain over a story she was covering.

Her natural weakness is jade, which keeps her from "ghosting" out and being able to pass through objects. She discovers she has the ability to teleport, but must cross a sort of "Hell" to do so.

Elisa faces a series of psionics, led by Dr. October, a woman who wanted to eliminate Elisa for being beautiful even in death. Elisa also must deal with a demon, Cameron Nemo, which escapes from her "hell".

Elisa's team-up with Barb Wire, a bounty hunter from Steel Harbor, results in Elisa receiving a warning that Archibald Scythe, a psionic from her past, is coming for her. Margo falls under Scythe's spell while an all-female paranormal team, the Furies, combines with Elisa to take him down.

What else can this sexy Ghost get into? The after-life has never been more fun!