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Weird Science is a mid-1990s American comedy series made for television, a spin-off of the 1985 movie of the same name.

The show follows the adventures of Gary Wallace (John Mallory Asher) and Wyatt Donnelly (Michael Manasseri), two socially inept high school students in an unspecified town in California (unlike the movie, which was set in Illinois). Together, using Wyatt's computer, they try to create a computer simulation of a perfect woman in order to practice communicating with women. However, a freak lightning storm brings the computer simulation to life, creating a real woman named Lisa (Vanessa Angel) - a drop-dead gorgeous genius with the powers of a "magic genie." The show followed in the tradition of '60s fantasy sitcoms like Bewitched and I Dream of Jeannie, combining a sitcom format with supernatural stories.

In the pilot episode, Gary claims that creating Lisa is possible because he "saw it in a John Hughes movie" - that is, of course, Weird Science.