The Ultimate Vampire Resource and Directory

During an assassination attempt, Paul Atreides (Muada'dib) is blinded and wanders off into the desert, never to be seen again (or so we think). His wife, Chani, has died giving birth to their twin children, Leto II and Ghanima, who are born with the same curse as Paul's sister, Alia. It is Alia who now rules as regent for the twins, but she is tortured by her own demons and voices in her head, brought on by overdosing on spice. The spice awakens what may be described as a race memory, and her Grandfather, the evil Baron Vladimir Harkonnen, begins to take over Aliaae's mind.

All of this instability on Dune prompts the Princess Wensicia to hatch her plot against the Atreides by killing the twins with genetically engineered predatory animals. A wanderer appears from the desert and starts preaching against the word of Muadae'dib, proclaiming that it is has been corrupted.

More civil war arises, this time on Arrakis itself. The twins escape the attack of the killer beasts, and, in doing so, are separated in the deep desert. Leto realises he must take on a new role and begins a period of mutation after "joining" with a baby worm.