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In the decade of 2080, on a lunar colony called Little America, a retired smuggler named Pluto Nash (Eddie Murphy) buys a nightclub in order to fulfill a longtime wish and to prevent the murder of its indebted owner, Anthony Frankowski (Jay Mohr), by his creditors. Seven years later, "Club Pluto" has become a successful business that is frequented by many socialites. The staff consists of Pluto, a Hispanic assistant, and an anthropomorphic android robot named Bruno (Randy Quaid). Meanwhile, Anthony has become a stage performer under the name 'Tony Francis', under which name he has achieved interplanetary fame despite his apparent lack of talent. His music, performance style, and costume resemble those of Frank Sinatra.
Pluto is approached one night by a young woman called Dina Lake (Rosario Dawson), who has become stranded on the Moon and desires to earn money to pay for transport to Earth. She seeks help from Pluto because her father, "Nicky Sticks", was a friend of Pluto's, to whom offers her skills as a singer. Instead, Pluto gives her a job as server at his club and allows her to remain after closure. During the same night, Pluto is approached three times by messengers of a mysterious entrepreneur called Rex Crater, who wishes to buy Club Pluto and convert it into a gambling casino. When Pluto refuses, Rex Crater's minions destroy the club. Pluto, Dina, and Bruno escape. They therafter begin to investigate Rex Crater, of whom very little is known. Rowland (Peter Boyle), a friend to Pluto's mother and retired police detective, informs Pluto that Rex Crater is never seen outside of a penthouse in the city of Moon Beach. Rex is said to have been involved with a geneticist named Runa Pendankin, who specialized in cloning, before her death....
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